![]() ![]() cyclosporine (Sandimmune, Neoral, Gengraf)Ĭertain medications are classified as D-level interactions, which means doctors or healthcare professionals should consider changing therapy.budesonide (Entocort, Uceris, Rhinocort Allergy).Drugs classified as an X-level interaction with grapefruit can include: This is because some interactions are classified as much more serious than others.Ĭertain medications are classified as an X-level interaction, which means the interactions are the most serious and you should avoid these combinations. Interaction with grapefruit juice is drug-specific, not drug category-specific.Īdditionally, the severity of the interaction can vary as well. Grapefruit juice doesn’t have an effect on every drug in the categories above. some anti-anxiety drugs, such as buspirone (BuSpar).antihistamines, such as fexofenadine (Allegra).drugs that treat abnormal heart rhythms, such as amiodarone (Pacerone, Cordarone).corticosteroids used to treat Crohn’s disease or ulcerative colitis, such as budesonide (Entocort EC, Uceris).immunosuppressive drugs, such as cyclosporine (Sandimmune, Neoral, Gengraf).drugs for high blood pressure, such as nifedipine (Procardia, Adalat CC).statins, such as simvastatin (Zocor) and atorvastatin (Lipitor).This can happen with certain medications when they interact with the chemicals in grapefruit.Īccording to the FDA, the following types of drugs can have a negative interaction with grapefruit: This means that you receive a little less of the drug in your bloodstream than the amount you initially consumed.īut when the enzyme is inhibited (prevented from working as it should) a dramatically larger amount of the drug makes its way into your bloodstream. Typically, when you take a drug orally, it’s broken down slightly by enzymes before it reaches the bloodstream. This enzyme helps break down the medication you take. Some of the chemicals found in grapefruit can bind to and inactivate an enzyme in the body that’s found in your intestines and liver. All forms of grapefruit - including freshly squeezed juice, frozen concentrate, pulp, and the whole fruit - can lead to drug interaction. Of these drugs, 43 of them can lead to serious adverse effects. There are more than 85 drugs that are known to interact with grapefruit. How drug interactions with grapefruit work ![]()
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